Job Opportunities

Senior / Principal Scientist, Medicinal Chemistry

Location: Boulder, CO

About the position

Enliven Therapeutics is dedicated to advancing small molecule drug development programs in oncology.  We are looking for a talented Senior / Principal Scientist, Medicinal Chemistry, Medicinal Chemistry to join our Chemistry team. This individual is responsible for leading a team of chemists to effectively design and synthesis novel compounds for ongoing and emerging projects, identification, and application of SAR to compound design, and team-driven optimization of clinical candidates. Responsibilities will also include managing CRO chemists and contribution to patent and publication preparation. This position reports to the VP of Chemistry.

Key Responsibilities

  • Lead from the bench as an expert of synthetic organic chemistry by solving problems and mentor junior chemists
  • Lead a team of chemists on the design and synthesis of drug-like molecules towards candidate selection
  • Lead a team of chemists for the route optimization of large scale synthesis of potential candidates
  • Contribute to new targets identification and medicinal chemistry proposals 
  • Contribute ideas for novel small molecules based on SAR, X-Ray crystallography and scientific literature
  • Oversee and effectively manage CRO chemists
  • Maintain close collaborations with fellow chemists and researchers across disciplines in a team environment
  • Maintain a command of relevant scientific literature and incorporate into individual project(s) as well as the overall program
  • Engage in medicinal chemistry discussions, prepare and present research results in chemistry and project team meetings
  • Prepare and deliver scientific presentations and data to colleagues within and outside the company
  • Maintain clear, detailed, and up-to-date records of research using electronic laboratory notebooks


  • BS, MS, or PhD in Organic Chemistry or related field with typically, 10+ (BS), 8+ (MS) or 5+ (PhD) years of experience; Postdoctoral or pharmaceutical industry experience preferable
  • Expert knowledge of ADME, physicochemical properties, and principles of medicinal chemistry
  • Proven track record of advancing projects from initiation to candidate selection
  • Demonstrate the ability to resolve key scientific hurdles by effectively utilizing available information and technical expertise
  • Excellent communication skills; ability to develop, implement and clearly communicate chemistry strategies and progress to team
  • Build strong relationships with peers and cross functionally with partners outside of teams to enable high performance
  • Self-motivated with the ability to work independently and effectively in a team-oriented, multidisciplinary environment
  • General scientific computer and software application proficiency


Interested applicants, please send resume to:

Enliven Therapeutics is proud to be an equal opportunity employer. All employment offers are contingent upon the applicant successfully completing a background screen.

Enliven Therapeutics does not accept resumes from recruitment agencies for this position. Recruiters, please do not send resumes to Enliven employees or to the company location. Enliven is not responsible for any fees related to unsolicited resumes.