About Us

We are a clinical-stage biopharmaceutical company focused on discovering and developing small molecule kinase inhibitors to address existing and emerging unmet needs in oncology. With a precision oncology approach, our aim is to improve survival and enhance overall well-being for cancer patients. 

Our discovery process combines clinically validated biological targets and industry-leading chemistry with the goal of designing best-in-class and first-in-class therapies. By focusing on these targets, we aim to develop drugs with a high probability of clinical success.

Learn more about our approach

Our Team

We have assembled a team with significant expertise in drug discovery and development with particular strength in the discovery of small molecule kinase inhibitors. Our team includes:

  • World-renowned chemists who have been the primary or co-inventor of over 20 product candidates that have been advanced to clinical trials, including four FDA-approved cancer therapies: Koselugo (selumetinib), Mektovi (binimetinib), Tukysa (tucatinib), and Retevmo (selpercatinib).
  • Precision oncology and kinase inhibitor experts who have led or been involved with the discovery, development, or commercialization of over 60 small molecule kinase inhibitor programs, including Imbruvica (ibrutinib), Vitrakvi (larotrectinib), Zydelig (idelalisib), ipatasertib (AKT inhibitor), and PF-07284890/ARRY-461 (CNS-penetrant BRAF inhibitor).
  • Leaders with a track record of success who have built or led research, development and commercial operations at companies including AbbVie, Array BioPharma, Genentech, Biogen, Pharmacyclics, Five Prime Therapeutics-Amgen, Gilead Sciences, and Blueprint Medicines.
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Sam Kintz, MBA

Co-founder, Chief Executive Officer, and Member of the Board of Directors

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Joe Lyssikatos, PhD

Co-founder, Chief Scientific Officer, and Member of the Board of Directors

Anish Patel photo

Anish Patel, PharmD

Co-founder and Chief Operating Officer

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Helen Collins, MD

Chief Medical Officer

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Ben Hohl

Chief Financial Officer and Head of Corporate Development

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Galya Blachman, PhD, Esq

Chief Legal Officer and Head of Business Development

Board of Directors

Scientific Advisors